Effects of 8 Week Strenuous Endurance and High Intensity Interval Training on Thioredoxin Reductase-1 enzyme and Malondialdehyde in Lung Tissue of Male Wistar rats

Introduction: Physical activity of any intensity and time effect on the oxidative stress and Antioxidant system. So, the proper choice of type, time and intensity of exercise is necessary. Therefore, the aim of the present study was to investigate the effect of 8 weeks of strenuous endurance (SET) and high intensity interval training (HIIT) on the TRX1 and MDA of lung tissue in male wistar rats. Methods: 24 male Wistar rats, were randomly divided into three groups: (Control, SET, HIIT). The training protocols were consisted SET and HIIT on a treadmill for 8 weeks (5 days a week). Forty-eight hours after the last session of training lung tissue samples were collected. Lung concentration of TRX1 was measured by ELISA and MDA concentration was measured by tribarbituric acid. To analyze the data, one-way ANOVA and Tukey's post hoc test were used. Results: The results of this study showed that after 8 weeks, there were no significant differences in TRX1 level of lung tissue in SET and HIIT groups compared to control group (p = 0/43). Also, there were no significant differences in MDA level of lung tissue in HIIT groups compared to control group (P = 0/06), but the level of MDA was significantly decreased in SET group compared to endurance group (P= 0/02). Conclusion: According to the results of this study, it can be concluded that 8-week SET, while reducing MDA, did not on TRX1 level of lung tissue.